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Welcome to the Rugarli lab!

Our group is interested in understanding how axons maintain their function during our lifetime and the mechanisms underlying their degeneration in neurological diseases, such as hereditary spastic paraplegia (HSP). HSP is characterised by the degeneration of axons of cortical motoneurons that control voluntary movements. These axons can reach the length of 1 m, contain up to 99% of the neuronal cytoplasm, and are highly dependent on efficient trafficking mechanisms to deliver proteins, lipids, and cellular organelles, including mitochondria, to distal regions.

Open questions that we address in our projects are:

  •  Which cellular pathways are dysfunctional in HSP and cause axonal degeneration?

  •   How is the quality and function of mitochondria regulated, especially in neurons and along axons?

Our aim is to elucidate the molecular, cellular and physiological function of crucial players in HSP and mitochondrial quality control.



Welcome to Alexander

We welcome our new lab manager Alexander, who joined our group this July.

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Goodbye to Desiree

We say goodbye to Desiree who did her PhD and later postdoctoral research in our group - it has been a wonderful time, full of exciting discoveries. ...

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New Review article out in May

Nimesha Tadepalle, Elena I. Rugarli, Lipid Droplets in the Pathogenesis of Hereditary Spastic Paraplegia, Front. Mol. Biosci., 10 May 2021 ...

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New publication on spastin

We published a new paper about spastin and its function in lipid droplet metabolism!


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New publication on CLUH!

We published a new paper on CLUH function in hepatocytes on EMBO Journal!

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Poster prize at the Tom-Wahlig Symposium 2019

Matteo Veronese and Lennart Robers won this years poster prize at the Tom-Wahlig Symposium in Weimar!

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Goodbye to Sara and Nimesha

As new members are joining our group, some old colleagues are leaving. We would like to say goodbye to Sara as well as Nimesha, who have been vital...

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New publication!

We published a new paper about an astrocyte specific deletion of the mitochondrial m-AAA protease that revealed glial contribution to...

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New publication!

Désirée Schatton and Elena Rugarli published a review about RNA binding proteins and their role in mitochondrial function. The review can be found...

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New lab member

We would like to welcome Carolina in our lab as a new PhD student. She will be the most recent addition in the team working on hereditary spastic...

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