CECAD Microsite

Our lab is interested in two main topics:

1) The pathogenic basis of hereditary spastic paraplegia


We aim to understand the mechanisms underlying axonal degeneration, a chronic process that plays an important role in several neurodegenerative diseases. We study the function of several proteins involved in hereditary spastic paraplegia, a disease characterized by degeneration of the corticospinal axons. Ultimately, we aim to a better understanding of the pathophysiology of this disease, and to unravel possible therapeutic avenues.

2) Regulatory mechanisms of mitochondrial function


Mitochondria are essential organelles involved in ATP production, Fe-S cluster biogenesis, calcium buffering, and several metabolic biosynthetic pathways. Mitochondrial homeostasis depends on regulated biogenesis and efficient quality control mechanisms, and is key to cell survival. Dysfunctional mitochondria can trigger apoptotic cell death, and play an important role in the pathogenesis of several diseases, including hereditary spastic paraplegia. We are investigating post-transcriptional mechanisms of regulation of mitochondrial biogenesis, as well as quality control pathways that are crucial to maintain the organelle function.


New lab member

We would like to welcome Matteo as a new PhD student in our lab. He will be working on hereditary spastic paraplegia. We hope you enjoy your time in...

Read more

Short talk at a Conference

Nimesha Tadepalle presented her data at the FASEB conference "Lipid Droplet on the move from health to disease" and won the travel award!

Read more

Goodbye Fiona

Fiona successfully finished her Bachelor Thesis in our lab! Congratulations from the entire lab to your very good Bachelor thesis, we wish you all the...

Read more

Goodbye David

After 3 years of successful work in the Rugarli lab, David continues to work on the biology of mitochondria in the lab of Prof. Dr. Rudolf Wiesner. We...

Read more

New lab member

We would like to welcome Marta to the Rugarli lab! We hope you enjoy working at the CECAD and wish you a successful time!

Read more

New Lab Member

We would like to welcome Fiona, who will do her bachelor's thesis in the Rugarli lab. Welcome and have a fun and successful time!

PhD position available!



There is a PhD Student position available in our group to study mechanisms of axonal degeneration in hereditary spastic paraplegia



Read more

New Lab member

We would like to welcome Mujeeb in our lab. He will do his PhD thesis in the Rugarli lab. We are happy that you joined the lab.

Read more

Goodbye Fenja

Fenja successfully finnished her master`s thesis in the Rugarli lab. We wish you all the best for your upcoming time as a Phd student.

Read more

Attending at a Conference

Desiree Schatton presents her data at Keystone symposium “Mitochondrial communication” in Taos, New Mexico: