CECAD Microsite

Our lab is interested in two main topics:

1) The pathogenic basis of hereditary spastic paraplegia

 

We aim to understand the mechanisms underlying axonal degeneration, a chronic process that plays an important role in several neurodegenerative diseases. We study the function of several proteins involved in hereditary spastic paraplegia, a disease characterized by degeneration of the corticospinal axons. Ultimately, we aim to a better understanding of the pathophysiology of this disease, and to unravel possible therapeutic avenues.

2) Regulatory mechanisms of mitochondrial function

 

Mitochondria are essential organelles involved in ATP production, Fe-S cluster biogenesis, calcium buffering, and several metabolic biosynthetic pathways. Mitochondrial homeostasis depends on regulated biogenesis and efficient quality control mechanisms, and is key to cell survival. Dysfunctional mitochondria can trigger apoptotic cell death, and play an important role in the pathogenesis of several diseases, including hereditary spastic paraplegia. We are investigating post-transcriptional mechanisms of regulation of mitochondrial biogenesis, as well as quality control pathways that are crucial to maintain the organelle function.

Lab-News

PhD position available!

 

 

There is a PhD Student position available in our group to study mechanisms of axonal degeneration in hereditary spastic paraplegia

 

A...

Read more

New Lab member

We would like to welcome Mujeeb in our lab. He will do his PhD thesis in the Rugarli lab. We are happy that you joined the lab.

Read more

Goodbye Fenja

Fenja successfully finnished her master`s thesis in the Rugarli lab. We wish you all the best for your upcoming time as a Phd student.

Read more

Attending at a Conference

Desiree Schatton presents her data at Keystone symposium “Mitochondrial communication” in Taos, New Mexico:

www.keystonesymposia.org/17A4


New Publication

Our new paper on the role of CLUH is online!

jcb.rupress.org/content/early/2017/02/09/jcb.201607019


New Lab member

We like to welcome Fenja as a new master student! Have a successful masters thesis and enjoy working in the Rugarli Lab.

Read more

Goodbye Kristina

After finishing her successful masters thesis, Kristina will leave the Lab. We wish her all the best for her upcoming PhD and please stop by when you...

Read more

Goodbye Shuaiyu

Shuaiyu successfully finished her Phd in the Rugarli lab! Congratulations to your degree and an outstanding puplication. We wish you the best for your...

Read more

New Lab member

We like to welcome a new master student to the Rugarli Lab. Lennart will do his master's thesis in our lab and will work for the next 6 month in the...

Read more

New Lab member

We like to welcome a new master student to our lab. Tsukasa will join the Rugarli group for 10 month. We wish you a lot of success and hope you enjoy...

Read more