CECAD Microsite

Our lab is interested in two main topics:

1) The pathogenic basis of hereditary spastic paraplegia

We aim to understand the mechanisms underlying axonal degeneration, a chronic process that plays an important role in several neurodegenerative diseases. We study the function of several proteins involved in hereditary spastic paraplegia, a disease characterized by degeneration of the corticospinal axons. Ultimately, we aim to a better understanding of the pathophysiology of this disease, and to unravel possible therapeutic avenues.

2) Regulatory mechanisms of mitochondrial function

Mitochondria are essential organelles involved in ATP production, Fe-S cluster biogenesis, calcium buffering, and several metabolic biosynthetic pathways. Mitochondrial homeostasis depends on regulated biogenesis and efficient quality control mechanisms, and is key to cell survival. Dysfunctional mitochondria can trigger apoptotic cell death, and play an important role in the pathogenesis of several diseases, including hereditary spastic paraplegia. We are investigating post-transcriptional mechanisms of regulation of mitochondrial biogenesis, as well as quality control pathways that are crucial to maintain the organelle function.

Lab-News

Attending at a Conference

Desiree Schatton presents her data at Keystone symposium “Mitochondrial communication” in Taos, New Mexico:

www.keystonesymposia.org/17A4


New Publication

Our new paper on the role of CLUH is online!

jcb.rupress.org/content/early/2017/02/09/jcb.201607019


New Lab member

We like to welcome Fenja as a new master student! Have a successful masters thesis and enjoy working in the Rugarli Lab.

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Goodbye Kristina

After finishing her successful masters thesis, Kristina will leave the Lab. We wish her all the best for her upcoming PhD and please stop by when you...

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Goodbye Shuaiyu

Shuaiyu successfully finished her Phd in the Rugarli lab! Congratulations to your degree and an outstanding puplication. We wish you the best for your...

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New Lab member

We like to welcome a new master student to the Rugarli Lab. Lennart will do his master's thesis in our lab and will work for the next 6 month in the...

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New Lab member

We like to welcome a new master student to our lab. Tsukasa will join the Rugarli group for 10 month. We wish you a lot of success and hope you enjoy...

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New Lab member

We are happy to announce that Marie joins our lab! We wish you best of luck and hope you are very successful with your studies!

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Goodbye Anja

Goodbye Anja! One of our master students successfully graduated. Good luck and the very best for your Phd in Cambridge!


Welcome Kristina

We are happy to welcome a new master student to our lab. Kristina will join the Rugarli lab for doing her masterthesis.

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