Research group “Mitochondrial dysfunction and mechanisms of axonal degeneration”
In an adult human individual, axons can reach the remarkable length of 1 meter and contain more than 99% of the cell cytoplasm. Survival of axons depends on efficient trafficking of organelles, cytoskeletal components, and lipid constituents synthesized in the cell body. The goal of our research is to understand the pathogenic mechanisms underlying axonal degeneration, a chronic process that plays an important role in several neurodegenerative diseases. We have a special interest in unravelling how mitochondrial dysfunction contributes to this process.