CECAD Microsite

Our lab is interested in two main topics:

1) The pathogenic basis of hereditary spastic paraplegia

 

We aim to understand the mechanisms underlying axonal degeneration, a chronic process that plays an important role in several neurodegenerative diseases. We study the function of several proteins involved in hereditary spastic paraplegia, a disease characterized by degeneration of the corticospinal axons. Ultimately, we aim to a better understanding of the pathophysiology of this disease, and to unravel possible therapeutic avenues.

2) Regulatory mechanisms of mitochondrial function

 

Mitochondria are essential organelles involved in ATP production, Fe-S cluster biogenesis, calcium buffering, and several metabolic biosynthetic pathways. Mitochondrial homeostasis depends on regulated biogenesis and efficient quality control mechanisms, and is key to cell survival. Dysfunctional mitochondria can trigger apoptotic cell death, and play an important role in the pathogenesis of several diseases, including hereditary spastic paraplegia. We are investigating post-transcriptional mechanisms of regulation of mitochondrial biogenesis, as well as quality control pathways that are crucial to maintain the organelle function.

Lab-News

Short talk at a Conference

Nimesha Tadepalle presented her data at the FASEB conference "Lipid Droplet on the move from health to disease" and won the travel award!

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Goodbye Fiona

Fiona successfully finished her Bachelor Thesis in our lab! Congratulations from the entire lab to your very good Bachelor thesis, we wish you all the...

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Goodbye David

After 3 years of successful work in the Rugarli lab, David continues to work on the biology of mitochondria in the lab of Prof. Dr. Rudolf Wiesner. We...

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New lab member

We would like to welcome Marta to the Rugarli lab! We hope you enjoy working at the CECAD and wish you a successful time!

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New Lab Member

We would like to welcome Fiona, who will do her bachelor's thesis in the Rugarli lab. Welcome and have a fun and successful time!


PhD position available!

 

 

There is a PhD Student position available in our group to study mechanisms of axonal degeneration in hereditary spastic paraplegia

 

A...

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New Lab member

We would like to welcome Mujeeb in our lab. He will do his PhD thesis in the Rugarli lab. We are happy that you joined the lab.

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Goodbye Fenja

Fenja successfully finnished her master`s thesis in the Rugarli lab. We wish you all the best for your upcoming time as a Phd student.

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Attending at a Conference

Desiree Schatton presents her data at Keystone symposium “Mitochondrial communication” in Taos, New Mexico:

www.keystonesymposia.org/17A4


New Publication

Our new paper on the role of CLUH is online!

jcb.rupress.org/content/early/2017/02/09/jcb.201607019